Intra-Dermal and Intra-Oral Vitamins and Minerals

Posted by Sayful-L-Islam Khan on

Intra-Dermal and Intra-Oral Vitamins and Minerals

Hello Nutra Friends,

Corny name I know, but anyways, I wanted to talk about something very important today. When we think of vitamins and minerals, the first thing that normally comes to mind are tablets and capsules that we ingest, just like medication. However, whilst I do not disagree with this method of consumption, there may be other ways that we can consume our vitamins and minerals. Yes, as the title mentions I am referring to intra-dermal (through the skin) and intra-oral (through the mouth to the bloodstream directly – not via the oesophagus) absorption.

There have been studies looking into this, for example in 2010, a study by Watkins K and Josling PD, found that when using a magnesium dermal spray the cellular magnesium in participants increased by 59.7% on average in just 12 weeks, where as oral supplementation has been reported to take 9-24 months for the same increase.1 This is because magnesium is absorbed poorly in the gut where as through the skin it is able to reach the blood stream more efficiently.

A similar concept can also be seen with certain vitamins we commonly supplement our diets with. A study by Satia et al., 2015 found that when a buccal spray of vitamin D was sprayed on the inner cheek, a significantly higher amount was absorbed into the bloodstream when compared to a typical formulation of soft gelatine capsules.2 In fact a study by Hassanali et al., 2012 found that when a buccal spray of vitamin D was sprayed into the inner cheek, roughly 20% of the total dose was absorbed, therefore enabling us to reach our Recommended Dietary  Allowance (RDA) more easily.3 This does not just apply to vitamin D, other vitamins also show similar results. In a study by Houston DM and Heard CM in 2013, they found that only one sublingual spray of vitamin B12 was enough to reach the RDA in in-vitro studies using a porcine sublingual membrane.4

Here at Nutracity, we like to back our recommendations with scientific and anecdotal evidence. This is just another example of this. Please click here to see our range of products in this category. Until next time……



  1. Watkins K and Josling PD A Pilot Study to determine the impact of Transdermal Magnesium treatment on serum levels and whole body CaMg Ratios www.phytomedcentral.org Date of publication 09/04/2010
  1. Satia MC, Mukim AG, Tibrewala KD, Bhavsar MS. A randomized two way cross over study for comparison of absorption of vitamin D3 buccal spray and soft gelatin capsule formulation in healthy subjects and in patients with intestinal malabsorption. Nutr J. 2015 Oct 29;14:114. doi: 10.1186/s12937-015-0105-1. PMID: 26514332; PMCID: PMC4627615.
  1. Hassanali et al. Analysis of the oral delivery of vitamin D3 from BetterYou DLux spray formulations, Cardiff School of Pharmacy & Pharmaceutical Sciences, Cardiff University 2012
  1. DM Houston, CM Heard In vitro analysis of sublingual vitamin B12 permeation, Cardiff School of Pharmacy & Pharmaceutical Sciences, Cardiff University 2013